/ Dictionary / Index M Mesoamerica: Meaning and Definition of Find definitions for: Mes•o•a•mer•i•ca Pronunciation: (mez"ō-u-mer'i-ku, mes"-, mē"zō-, -sō-), [key] — n. the area extending approximately from central Mexico to Honduras and Nicaragua in which diverse pre-Columbian civilizations flourished. (loosely) Central America. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: mesoamerica (Thesaurus) meso- mesoappendix Related Content Daily Word Quiz: panacea Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language