/ Dictionary / Index A agonist: Meaning and Definition of Find definitions for: ag•o•nist Pronunciation: (ag'u-nist), [key] — n. a person engaged in a contest, conflict, struggle, etc., esp. the protagonist in a literary work. a person who is torn by inner conflict. a contracting muscle whose action is opposed by another muscle. Cf. antagonist (def. 3). a chemical substance capable of activating a receptor to induce a full or partial pharmacological response. Cf. antagonist (def. 5). Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: agonist (Thesaurus) agonic line agonistic Related Content Daily Word Quiz: perspicacious Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language