/ Dictionary / Index A alpha and omega: Meaning and Definition of Find definitions for: al'pha and ome'ga Pronunciation: [key] the beginning and the end. Rev. 1:8. the basic or essential element or elements: the alpha and omega of political reform. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. alpha-adrenergic receptor alphabet Related Content Daily Word Quiz: pedagogy Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language