/ Dictionary / Index C centromere: Meaning and Definition of Find definitions for: cen•tro•mere Pronunciation: (sen'tru-mēr"), [key] — n. Cell Biol. a specialized structure on the chromosome, appearing during cell division as the constricted central region where the two chromatids are held together and form anshape. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: centromere (Thesaurus) centrolinead centrosome Related Content Daily Word Quiz: lyre Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language