/ Dictionary / Index C CISC: Meaning and Definition of Find definitions for: CISC Pronunciation: (sisk), [key] complex instruction set computer: a computer whose central processing unit recognizes a relatively large number of instructions. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: cisc (Thesaurus) cisatlantic Ciscaucasia Related Content Daily Word Quiz: perspicacious Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language