/ Dictionary / Index C craniotomy: Meaning and Definition of Find definitions for: cra•ni•ot•o•my Pronunciation: (krā"nē-ot'u-mē), [key] — pl. -mies. the operation of opening the skull, usually for operations on the brain. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: craniotomy (Thesaurus) cranioscopy cranium Related Content Daily Word Quiz: penurious Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language