/ Dictionary / Index C cross-tolerance: Meaning and Definition of Find definitions for: cross-tol•er•ance Pronunciation: (krôs'tol'ur-uns, kros'-), [key] — n. Physiol. the resistance to one or more effects of a substance because of tolerance to a pharmacologically similar substance: a cross-tolerance of some alcoholics to anesthetics. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. crosstie crosstown Related Content Daily Word Quiz: arboreal Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language