/ Dictionary / Index D Department of State: Meaning and Definition of Find definitions for: Depart'ment of State' Pronunciation: [key] the department of the U.S. federal government that sets forth and maintains the foreign policy of the U.S., esp. in negotiations with foreign governments and international organizations. Abbr.: DOS Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Department of Labor Department of the Interior Related Content Daily Word Quiz: paradox Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language