/ Dictionary / Index D department store: Meaning and Definition of Find definitions for: depart'ment store" Pronunciation: [key] a large retail store carrying a wide variety of merchandise and organized into various departments for sales and administrative purposes. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Department of Transportation departure Related Content Daily Word Quiz: paradox Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language