/ Dictionary / Index D deplete: Meaning and Definition of Find definitions for: de•plete Pronunciation: (di-plēt'), [key] — -plet•ed, -plet•ing. to decrease seriously or exhaust the abundance or supply of: The fire had depleted the game in the forest. Extravagant spending soon depleted his funds. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: deplete (Thesaurus) de plano depletion allowance Related Content Daily Word Quiz: serendipity Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language