/ Dictionary / Index D De Soto: Meaning and Definition of Find definitions for: De So•to Pronunciation: (du sō'tō Sp. de sô'tô), [key] orc1500–42, Spanish soldier and explorer in America. a city in NE Texas. 15,538. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. desorb desoxy- Related Content Daily Word Quiz: belligerent Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language