/ Dictionary / Index D despair: Meaning and Definition of Find definitions for: de•spair Pronunciation: (di-spâr'), [key] — n. loss of hope; hopelessness. someone or something that causes hopelessness: He is the despair of his mother. —v.i. to lose, give up, or be without hope (often fol. by of&hasp;): to despair of humanity. —v.t. to give up hope of. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: despair (Thesaurus) desoxy- despairing Related Content Daily Word Quiz: arid Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language