/ Dictionary / Index D disaffection: Meaning and Definition of Find definitions for: dis•af•fec•tion Pronunciation: (dis"u-fek'shun), [key] — n. the absence or alienation of affection or goodwill; estrangement; disloyalty: Disaffection often leads to outright treason. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: disaffection (Thesaurus) disaffected disaffiliate Related Content Daily Word Quiz: modify Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language