/ Dictionary / Index D downstream: Meaning and Definition of Find definitions for: down•stream Pronunciation: (doun'strēm'), [key] — adv. with or in the direction of the current of a stream. —adj. of or pertaining to the latter part of a process or system. with or in the direction of transcription, translation, or synthesis of a DNA, RNA, or protein molecule. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: downstream (Thesaurus) downstate downstroke Related Content Daily Word Quiz: reclusive Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language