/ Dictionary / Index E East St. Louis: Meaning and Definition of Find definitions for: East St. Louis Pronunciation: [key] a city in SW Illinois, across the Mississippi River from St. Louis, Missouri. 55,200. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. east-southeast East Suffolk Related Content Daily Word Quiz: fresco Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language