/ Dictionary / Index E Edessa: Meaning and Definition of Find definitions for: E•des•sa Pronunciation: (i-des'u), [key] — n. an ancient city in NW Mesopotamia, on the modern site of Urfa: an early center of Christianity; the capital of a principality under the Crusaders. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. EDES edetate calcium disodium Related Content Daily Word Quiz: paradox Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language