/ Dictionary / Index E empty nest syndrome: Meaning and Definition of Find definitions for: emp'ty nest' syn"drome Pronunciation: [key] a depressed state felt by some parents after their children have left home. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. empty nester Empty Quarter Related Content Daily Word Quiz: paradox Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language