/ Dictionary / Index E encephalomalacia: Meaning and Definition of Find definitions for: en•ceph•a•lo•ma•la•cia Pronunciation: (en-sef"u-lō-mu-lā'shu, -shē-u), [key] — n. Pathol. a softness or degeneration of brain tissue, as caused by impairment of the blood supply; softening of the brain. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. encephaloma encephalomyelitis Related Content Daily Word Quiz: nonchalant Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language