/ Dictionary / Index E epicardium: Meaning and Definition of Find definitions for: ep•i•car•di•um Pronunciation: (ep"i-kär'dē-um), [key] — pl. -di•a the inner serous layer of the pericardium, lying directly upon the heart. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: epicardium (Thesaurus) epicanthus epicarp Related Content Daily Word Quiz: pristine Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language