/ Dictionary / Index E epistle: Meaning and Definition of Find definitions for: e•pis•tle Pronunciation: (i-pis'ul), [key] — n. a letter, esp. a formal or didactic one; written communication. (usually cap.) one of the apostolic letters in the New Testament. (often cap.) an extract, usually from one of the Epistles of the New Testament, forming part of the Eucharistic service in certain churches. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: epistle (Thesaurus) episternum epistle side Related Content Daily Word Quiz: supercilious Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language