/ Dictionary / Index E excruciate: Meaning and Definition of Find definitions for: ex•cru•ci•ate Pronunciation: (ik-skr'shē-āt"), [key] — -at•ed, -at•ing. to inflict severe pain upon; torture: The headache excruciated him. to cause mental anguish to; irritate greatly. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: excruciate (Thesaurus) excretory excruciating Related Content Daily Word Quiz: cetacean Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language