/ Dictionary / Index G general post office: Meaning and Definition of Find definitions for: gen'eral post' of"fice Pronunciation: [key] (in the U.S. postal system) the main post office of a city, county, etc., that also has branch post offices. Abbr.: G.P.O., GPO Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. General Postal Union general practice Related Content Daily Word Quiz: perspicacious Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language