/ Dictionary / Index G Great Plague: Meaning and Definition of Find definitions for: Great' Plague' Pronunciation: [key] the bubonic plague that occurred in London in 1665 and killed about 15 percent of the city's population. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. great pastern bone Great Plains Related Content Daily Word Quiz: resilient Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language