/ Dictionary / Index G guff: Meaning and Definition of Find definitions for: guff Pronunciation: (guff), [key] — n. Informal. empty or foolish talk; nonsense. insolent talk. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: guff (Thesaurus) Guevarist guffaw Related Content Daily Word Quiz: endear Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language