/ Dictionary / Index H Harlem: Meaning and Definition of Find definitions for: Har•lem Pronunciation: (här'lum), [key] — n. a section of New York City, in the NE part of Manhattan. a tidal river in New York City, between the boroughs of Manhattan and the Bronx, which, with Spuyten Duyvil Creek, connects the Hudson and East rivers. 8 mi. (13 km) long. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: harlem (Thesaurus) Harleian Library Harlemite Related Content Daily Word Quiz: vertigo Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language