/ Dictionary / Index H histidine: Meaning and Definition of Find definitions for: his•ti•dine Pronunciation: (his'ti-dēn", -din), [key] — n. Biochem. an essential amino acid, CHNCHCH(NH)COOH, that is a constituent of proteins and is important as the iron-binding site in hemoglobin. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: histidine (Thesaurus) histamine headache histioid Related Content Daily Word Quiz: inutiae Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language