/ Dictionary / Index H histone: Meaning and Definition of Find definitions for: his•tone Pronunciation: (his'tōn), [key] — n. Biochem. any of a group of five small basic proteins, occurring in the nucleus of eukaryotic cells, that organize DNA strands into nucleosomes by forming molecular complexes around which the DNA winds. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: histone (Thesaurus) histomorphology histopathology Related Content Daily Word Quiz: profiterole Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language