/ Dictionary / Index H Holy One: Meaning and Definition of Find definitions for: Ho'ly One" Pronunciation: [key] God. Isa. 10:20. Jesus Christ, esp. as the Messiah. Mark 1:24; Acts 3:14. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Holyoke holy orders Related Content Daily Word Quiz: bungled Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language