/ Dictionary / Index H home office: Meaning and Definition of Find definitions for: home' of'fice Pronunciation: [key] the main office of a company. (caps.) the governmental department in Great Britain dealing with domestic matters, as elections, naturalization, and the control of police. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. homeobox gene homeomorph Related Content Daily Word Quiz: simian Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language