/ Dictionary / Index H hopeful monster: Meaning and Definition of Find definitions for: hope'ful mon'ster Pronunciation: [key] — Biol. Biol. a hypothetical individual organism that, by means of a fortuitous macromutation permitting an adaptive shift to a new mode of life, becomes the founder of a new type of organism and a vehicle of macroevolution. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. hopefully Hopeh Related Content Daily Word Quiz: serendipity Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language