/ Dictionary / Index H hypersplenism: Meaning and Definition of Find definitions for: hy•per•splen•ism Pronunciation: (hī"pur-splē'niz-um, -splen'iz-), [key] — n. Pathol. an abnormal condition characterized by an enlarged spleen that prematurely destroys red blood cells or platelets. Also called Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: hypersplenism (Thesaurus) hypersphere hyperstatic Related Content Daily Word Quiz: simian Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language