/ Dictionary / Index H hypodermis: Meaning and Definition of Find definitions for: hy•po•der•mis Pronunciation: (hī"pu-dûr'mis), [key] — n. an underlayer of epithelial cells in arthropods and certain other invertebrates that secretes substances for the overlying cuticle or exoskeleton. a tissue or layer of cells beneath the epidermis. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: hypodermis (Thesaurus) hypodermic syringe hypodorian mode Related Content Daily Word Quiz: fabricate Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language