/ Dictionary / Index I Interstate Commerce Commission: Meaning and Definition of Find definitions for: In'terstate Com'merce Commis"sion Pronunciation: [key] — U.S. Govt. U.S. Govt. a board, consisting of seven members, that supervises and regulates all carriers, except airplanes, engaged in interstate commerce. Abbr.: I.C.C., ICC Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. interstate Interstate Highway System Related Content Daily Word Quiz: spectral Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language