/ Dictionary / Index I IOU: Meaning and Definition of Find definitions for: IOU Pronunciation: [key] a written acknowledgment of a debt, esp. an informal one consisting only of the letters IOU, the sum owed, and the debtor's signature. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: iou (Thesaurus) iotacism -ious Related Content Daily Word Quiz: secular Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language