/ Dictionary / Index I irritation: Meaning and Definition of Find definitions for: ir•ri•ta•tion Pronunciation: (ir"i-tā'shun), [key] — n. the act of irritating or the state of being irritated. something that irritates. the bringing of a bodily part or organ to an abnormally excited or sensitive condition. the condition itself. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: irritation (Thesaurus) irritating irritative Related Content Daily Word Quiz: penury Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language