/ Dictionary / Index I Issus: Meaning and Definition of Find definitions for: Is•sus Pronunciation: (is'us), [key] — n. an ancient town in Asia Minor, in Cilicia: victory of Alexander the Great over Darius III 333 b.c. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: issus (Thesaurus) issue par Issyk-Kul Related Content Daily Word Quiz: spectral Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language