/ Dictionary / Index I Ithaca: Meaning and Definition of Find definitions for: Ith•a•ca Pronunciation: (ith'u-ku), [key] — n. one of the Ionian Islands, off the W coast of Greece: legendary home of Ulysses. 4156; 37 sq. mi. (96 sq. km). a city in S New York at the S end of Cayuga Lake. 28,732. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: ithaca (Thesaurus) iterative ither Related Content Daily Word Quiz: spectral Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language