/ Dictionary / Index L lobe: Meaning and Definition of Find definitions for: lobe Pronunciation: (lōb), [key] — n. a roundish projection or division, as of an organ or a leaf. earlobe. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: lobe (Thesaurus) lobbyist lobectomy Related Content Daily Word Quiz: tactful Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language