/ Dictionary / Index L lobotomize: Meaning and Definition of Find definitions for: lo•bot•o•mize Pronunciation: (lu-bot'u-mīz", lō-), [key] — -mized, -miz•ing. to perform a lobotomy on. to make (someone or something) abnormally tranquil or sluggish. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. lobose lobotomized Related Content Daily Word Quiz: exemplary Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language