/ Dictionary / Index L lobotomy: Meaning and Definition of Find definitions for: lo•bot•o•my Pronunciation: (lu-bot'u-mē, lō-), [key] — pl. -mies. the operation of cutting into a lobe, as of the brain or the lung. See Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: lobotomy (Thesaurus) lobotomized lobscouse Related Content Daily Word Quiz: tactful Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language