/ Dictionary / Index L lupus: Meaning and Definition of Find definitions for: lu•pus Pronunciation: (l'pus), [key] — n. Pathol. See See Lu•pus Pronunciation: (l'pus), [key] — gen. -pi the Wolf, a southern constellation between Centaurus and Norma. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: lupus (Thesaurus) lupulin lupus erythematosus Related Content Daily Word Quiz: benevolent Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language