/ Dictionary / Index M main chance: Meaning and Definition of Find definitions for: main' chance' Pronunciation: [key] an opportunity offering the greatest gain: Being ambitious, he always had an eye for the main chance. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. main brace main clause Related Content Daily Word Quiz: morose Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language