/ Dictionary / Index M mainframe: Meaning and Definition of Find definitions for: main•frame Pronunciation: (mān'frām"), [key] — n. Computers. a large computer, often the hub of a system serving many users. Cf. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: mainframe (Thesaurus) main-force main gauche Related Content Daily Word Quiz: censure Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language