/ Dictionary / Index M main street: Meaning and Definition of Find definitions for: main' street" Pronunciation: [key] the principal thoroughfare, esp. through the business district, in a small town. (caps.) the outlook, environment, or life of a small town. Main' Street" Pronunciation: [key] a novel (1920) by Sinclair Lewis. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. mainstreaming maintain Related Content Daily Word Quiz: perspicacious Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language