/ Dictionary / Index M mandrel: Meaning and Definition of Find definitions for: man•drel Pronunciation: (man'drul), [key] — n. Mach. a shaft or bar the end of which is inserted into a workpiece to hold it during machining. a spindle on which a circular saw or grinding wheel rotates. the driving spindle in the headstock of a lathe. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: mandrel (Thesaurus) mandrake mandrill Related Content Daily Word Quiz: portent Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language