/ Dictionary / Index M monosome: Meaning and Definition of Find definitions for: mon•o•some Pronunciation: (mon'u-sōm"), [key] — n. Genetics. a chromosome having no homologue, esp. an unpaired X chromosome. a protein-synthetic complex involving the translation of a messenger RNA molecule by a single ribosome. a monosomic individual. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. monosodium glutamate monosomic Related Content Daily Word Quiz: diurnal Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language