/ Dictionary / Index M M.S.M.E.: Meaning and Definition of Find definitions for: M.S.M.E. Pronunciation: [key] Master of Science in Mechanical Engineering. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. M.S.M. M.S.Met.E. Related Content Daily Word Quiz: tactful Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language