/ Dictionary / Index N nettlesome: Meaning and Definition of Find definitions for: net•tle•some Pronunciation: (net'l-sum), [key] — adj. causing irritation, vexation, or annoyance: to cope with a nettlesome situation. easily provoked or annoyed: to become nettlesome over trivial matters. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: nettlesome (Thesaurus) nettle rash net ton Related Content Daily Word Quiz: eureka Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language