/ Dictionary / Index N nuclease: Meaning and Definition of Find definitions for: nu•cle•ase Pronunciation: (n'klē-ās", -āz", ny'-), [key] — n. Biochem. any enzyme that catalyzes the hydrolysis of nucleic acids. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: nuclease (Thesaurus) nuclear winter nucleate Related Content Daily Word Quiz: portent Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language