/ Dictionary / Index O Opechancanough: Meaning and Definition of Find definitions for: O•pech•an•ca•nough Pronunciation: (ō-pech"un-kä'nō), [key] — n. c1545–1644, Algonquian leader, brother of Powhatan: led Jamestown massacre 1622. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. OPEC Op-Ed Related Content Daily Word Quiz: panacea Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language